Yes. You can end a custom group before its expiry date by either modifying its expiry date or deleting the group.
The expiry date can be modified by navigating to Policy Map > Custom Groups and selecting the edit icon from the “More” icon (...) for the Custom Group you want to edit. You would need to select a new end date in the “Duration” field. Note that the group will expire at midnight of the expiry date selected.
To delete a group click the “Delete” icon for the Custom Group you want to end.